Hydrochloric Acid → HCID 68700893, compound

Participants

Reaction Steps

A mixture of 4-amino-1,5-bis(4-isopropoxyphenyl)indole-2-carboxylic acid ethyl ester (160 mg, 340 nmol; see step (a)), acetonitrile (5 mL), and aqueous NaOH (1M, 2 mL) was heated at reflux for 3 h, and then allowed to cool. The pH was adjusted to 7 with 1 M HCl, and the mixture extracted with EtOAc. The combined extracts were washed with brine, dried over Na2SO4, concentrated, purified by chromatography, and dissolved in Et2O/absolute ethanol (3 mL). 4M HCl (100 μL) in dioxane was added. The precipitate was filtered off, washed with Et2O, and dried to yield the title compound (124 mg, 86%).

Provenance & Evidence