Hydrochloric Acid → HCID 68695991, compound

Participants

Reaction Steps

A mixture of 4-amino-1,5-bis(4-isopropoxyphenyl)indole-2-carboxylic acid ethyl ester (160 mg, 0.34 mmol; see Example 5(a)), acetyl chloride (50 mg, 0.63 mmol), Et3N (63 mg, 0.63 mmol) and MeCN (10 mL) was stirred at room temperature for 30 minutes, then poured into HCl (1M) and extracted with EtOAc. The combined extracts were washed with water and brine, and dried over Na2SO4. Concentration and purification by chromatography gave the sub-title compound (182 mg, 84%).

Provenance & Evidence