4-Bromoanisole → HCID 68702458, compound

HRID 646106Notes

Reaction equation

C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([C:15]1[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:24])[F:23])=[CH:17][CH:16]=1)=[CH:10][CH:9]=2)=[O:5])C.Br[C:27]1[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][CH:28]=1>>[CH3:34][O:33][C:30]1[CH:31]=[CH:32][C:27]([N:7]2[C:8]3[C:13](=[CH:12][C:11]([C:15]4[CH:16]=[CH:17][C:18]([O:21][C:22]([F:23])([F:25])[F:24])=[CH:19][CH:20]=4)=[CH:10][CH:9]=3)[CH:14]=[C:6]2[C:4]([OH:3])=[O:5])=[CH:28][CH:29]=1

Participants

Reactant 2

HCID 77304-Bromoanisole

HCID 68696822HCID 68696822, compound

Product 1

HCID 68702458HCID 68702458, compound

Procedure

The title compound was prepared from 5-(4-(trifluoromethoxy)-phenyl)indole-2-carboxylic acid ethyl ester (prepared in accordance with Example 1(a) from 5-bromoindole-2-carboxylic acid ethyl ester and 4-(trifluoromethoxy)phenylboronic acid) and 1-bromo-4-methoxybenzene in accordance with the procedure described in Example 9(b), followed by hydrolysis in accordance with the procedure described in Example 1(c).

Workup

customfollowed by hydrolysis in accordance with the procedure

Sources & evidence

ORD record: ord-650939422286454f81aceade397f30d7
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07705023B2

Reaction notes

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