2-Chloro-5-(ethoxymethyl)pyridine → 1-(5-(Ethoxymethyl)pyrid-2-yl)-5-(4-isopropoxyphenyl)indole-2-carboxylic acid
Reaction equation
C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([C:15]1[CH:20]=[CH:19][C:18]([O:21][CH:22]([CH3:24])[CH3:23])=[CH:17][CH:16]=1)=[CH:10][CH:9]=2)=[O:5])C.Cl[C:26]1[CH:31]=[CH:30][C:29]([CH2:32][O:33][CH2:34][CH3:35])=[CH:28][N:27]=1>>[CH2:34]([O:33][CH2:32][C:29]1[CH:30]=[CH:31][C:26]([N:7]2[C:8]3[C:13](=[CH:12][C:11]([C:15]4[CH:16]=[CH:17][C:18]([O:21][CH:22]([CH3:23])[CH3:24])=[CH:19][CH:20]=4)=[CH:10][CH:9]=3)[CH:14]=[C:6]2[C:4]([OH:3])=[O:5])=[N:27][CH:28]=1)[CH3:35]Participants
3
Procedure
The title compound was prepared in accordance with Example 10 using 5-(4-isopropoxyphenyl)indole-2-carboxylic acid ethyl ester and 2-chloro-5-(ethoxymethyl)pyridine.
Sources & evidence
- ORD record
- ord-7e6916944e244da09908296ab0f8489f
- Source dataset
- uspto-grants-2010_04
- Patent number
- US07705023B2
Reaction notes
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