5-Bromo-2-(1-methylethoxy)pyridine → 5-(4-Isopropoxyphenyl)-1-(6-isopropoxypyrid-3-yl)indole-2-carboxylic acid

HRID 646111Notes

Reaction equation

HRID 646111 reaction equation
C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([C:15]1[CH:20]=[CH:19][C:18]([O:21][CH:22]([CH3:24])[CH3:23])=[CH:17][CH:16]=1)=[CH:10][CH:9]=2)=[O:5])C.Br[C:26]1[CH:27]=[CH:28][C:29]([O:32][CH:33]([CH3:35])[CH3:34])=[N:30][CH:31]=1>>[CH:22]([O:21][C:18]1[CH:17]=[CH:16][C:15]([C:11]2[CH:12]=[C:13]3[C:8](=[CH:9][CH:10]=2)[N:7]([C:26]2[CH:31]=[N:30][C:29]([O:32][CH:33]([CH3:35])[CH3:34])=[CH:28][CH:27]=2)[C:6]([C:4]([OH:3])=[O:5])=[CH:14]3)=[CH:20][CH:19]=1)([CH3:23])[CH3:24]

Participants

3

Reactant 2

HCID 219350685-Bromo-2-(1-methylethoxy)pyridineHCID 68696575HCID 68696575, compound

Product 1

HCID 686968305-(4-Isopropoxyphenyl)-1-(6-isopropoxypyrid-3-yl)indole-2-carboxylic acid

Procedure

The title compound was prepared in accordance with Example 10 using 5-(4-isopropoxyphenyl)indole-2-carboxylic acid ethyl ester and 5-bromo-2-isopropoxypyridine.

Sources & evidence

ORD record
ord-b8ff46284d8247799322297153dc0d3a
Source dataset
uspto-grants-2010_04
Patent number
US07705023B2

Reaction notes

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