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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 646115Generated: October 29, 2026

4-(Trifluoromethoxy)phenylboronic acid → 5-(4-tert-Butylphenyl)-1-(4-(trifluoromethoxy)phenyl)indole-2-carboxylic acid

https://huagongshe.com/reaction/646115

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethoxy)phenylboronic acidHCID 2734386—
ReactantEthyl 5-(4-(tert-butyl)phenyl)-1H-indole-2-carboxylateHCID 68475095—
Product5-(4-tert-Butylphenyl)-1-(4-(trifluoromethoxy)phenyl)indole-2-carboxylic acidHCID 68700098—

Reaction Steps

The title compound was prepared in accordance with Example 8(c) using 5-(4-tert-butylphenyl)indole-2-carboxylic acid ethyl ester and 4-(trifluoromethoxy)phenylboronic acid, followed by hydrolysis in accordance with the procedure described in Example 1(c).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07705023B2
Source datasetuspto-grants-2010_04
ORD IDord-1cdfcb98f2cb49e480e63550e8c982bb
Source noteuspto-grants-2010_04