2-Bromo-6-(propan-2-yloxy)naphthalene → 5-(4-tert-Butylphenyl)-1-(6-isopropoxy-2-naphthyl)indole-2-carboxylic acid

HRID 646119Notes

Reaction equation

HRID 646119 reaction equation
C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([C:15]1[CH:20]=[CH:19][C:18]([C:21]([CH3:24])([CH3:23])[CH3:22])=[CH:17][CH:16]=1)=[CH:10][CH:9]=2)=[O:5])C.Br[C:26]1[CH:35]=[CH:34][C:33]2[C:28](=[CH:29][CH:30]=[C:31]([O:36][CH:37]([CH3:39])[CH3:38])[CH:32]=2)[CH:27]=1>>[C:21]([C:18]1[CH:17]=[CH:16][C:15]([C:11]2[CH:12]=[C:13]3[C:8](=[CH:9][CH:10]=2)[N:7]([C:26]2[CH:35]=[CH:34][C:33]4[C:28](=[CH:29][CH:30]=[C:31]([O:36][CH:37]([CH3:39])[CH3:38])[CH:32]=4)[CH:27]=2)[C:6]([C:4]([OH:5])=[O:3])=[CH:14]3)=[CH:20][CH:19]=1)([CH3:24])([CH3:22])[CH3:23]

Participants

3

Reactant 2

HCID 542230802-Bromo-6-(propan-2-yloxy)naphthaleneHCID 68475095Ethyl 5-(4-(tert-butyl)phenyl)-1H-indole-2-carboxylate

Product 1

HCID 686955975-(4-tert-Butylphenyl)-1-(6-isopropoxy-2-naphthyl)indole-2-carboxylic acid

Procedure

The title compound was prepared in accordance with Example 1 using 5-(4-tert-butylphenyl)indole-2-carboxylic acid ethyl ester and 2-bromo-6-isopropoxynaphthalene.

Sources & evidence

ORD record
ord-4b959ecc5ed645619cf69eed5a44483b
Source dataset
uspto-grants-2010_04
Patent number
US07705023B2

Reaction notes

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