1-Bromo-4-nitrobenzene → 5-(4-tert-Butylphenyl)-1-(4-nitrophenyl)indole-2-carboxylic acid ethyl ester

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5-(4-tert-Butylphenyl)-1-(4-nitrophenyl)indole-2-carboxylic acid ethyl ester was prepared in accordance with Example 1 using 5-(4-tert-butylphenyl)indole-2-carboxylic acid ethyl ester and 1-bromo-4-nitrobenzene. This ester (207 mg, 0.47 mmol) was dissolved in dioxane (2 mL) to which aqueous NaOH (1M, 1 mL) was added. The mixture was heated using microwave irradiation at 120° C. for 15 min and allowed to cool. The precipitate was filtered off, washed with water and recrystallised from EtOH/EtOAc to yield the title compound.

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