Pyridine → 1-(4-Bromophenylsulfonyl)-4-methylpiperazine

Participants

Role	Name	HCID	Charge
Reactant	Pyridine	HCID 1049	—
Reactant	p-Bromobenzenesulfonyl chloride	HCID 7396	—
Reactant	1-Methylpiperazine	HCID 53167	—
Solvent	Dichloromethane	HCID 6344	—
Product	1-(4-Bromophenylsulfonyl)-4-methylpiperazine	HCID 710729	71.1%

Reaction Steps

4-Bromobenzene-1-sulfonyl chloride (2.56 g, 10 mmol) in anhydrous CH2Cl2 (10 mL) was added to a mixture of 1-methylpiperazine (2.0 g, 20 mmol), pyridine (2.37 g, 30 mmol) and anhydrous CH2Cl2 (10 mL) at 0° C. The mixture was stirred at room temperature for 16 h, concentrated, recrystallised, and dried over P2O5 to yield the sub-title compound (2.27 g, 71%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07705023B2
Source dataset	uspto-grants-2010_04
ORD ID	ord-72b8d0f8624b444f9fe42320d189c2b6
Source note	uspto-grants-2010_04