HRID646128

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCOC(=O)c1cc2cc(-c3ccc(C(C)(C)C)cc3)ccc2[nH]1

HCID68475095

未命名化合物

结构：CN1CCN(C(=O)C(C)(C)Oc2ccc(Br)cc2)CC1.Cl

HCID68697500

未命名化合物

PRODUCTS

生成物

结构：CN1CCN(C(=O)C(C)(C)Oc2ccc(-n3c(C(=O)O)cc4cc(-c5ccc(C(C)(C)C)cc5)ccc43)cc2)CC1.Cl

HCID68697296

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in accordance with Example 1 using 5-(4-tert-butylphenyl)indole-2-carboxylic acid ethyl ester and 1-(2-(4-bromophenoxy)-2-methylpropanoyl)-4-methylpiperazine hydrochloride (see (a)), followed by precipitation of the hydrochloride salt using HCl (4 M in dioxane).

WORKUP

后处理

customfollowed by precipitation of the hydrochloride salt

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-66bb25cfd454418f81a37bc14649eee9
来源数据集: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07705023B2
来源说明: uspto-grants-2010_04

反应 SMILES

C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([C:15]1[CH:20]=[CH:19][C:18]([C:21]([CH3:24])([CH3:23])[CH3:22])=[CH:17][CH:16]=1)=[CH:10][CH:9]=2)=[O:5])C.[ClH:25].Br[C:27]1[CH:45]=[CH:44][C:30]([O:31][C:32]([CH3:43])([CH3:42])[C:33]([N:35]2[CH2:40][CH2:39][N:38]([CH3:41])[CH2:37][CH2:36]2)=[O:34])=[CH:29][CH:28]=1>>[ClH:25].[C:21]([C:18]1[CH:17]=[CH:16][C:15]([C:11]2[CH:12]=[C:13]3[C:8](=[CH:9][CH:10]=2)[N:7]([C:27]2[CH:45]=[CH:44][C:30]([O:31][C:32]([CH3:43])([CH3:42])[C:33]([N:35]4[CH2:40][CH2:39][N:38]([CH3:41])[CH2:37][CH2:36]4)=[O:34])=[CH:29][CH:28]=2)[C:6]([C:4]([OH:5])=[O:3])=[CH:14]3)=[CH:20][CH:19]=1)([CH3:24])([CH3:22])[CH3:23]