Ethyl 5-Bromoindole-2-carboxylate → 5-Bromo-1-(4-isopropoxyphenyl)indole-2-carboxylic acid ethyl ester

HRID 646131Notes

Reaction equation

HRID 646131 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([Br:15])=[CH:10][CH:9]=2)=[O:5])[CH3:2].[CH:16]([O:19][C:20]1[CH:25]=[CH:24][C:23](B(O)O)=[CH:22][CH:21]=1)([CH3:18])[CH3:17]>>[CH2:1]([O:3][C:4]([C:6]1[N:7]([C:23]2[CH:24]=[CH:25][C:20]([O:19][CH:16]([CH3:18])[CH3:17])=[CH:21][CH:22]=2)[C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([Br:15])=[CH:10][CH:9]=2)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 259091Ethyl 5-Bromoindole-2-carboxylateHCID 36987264-Isopropoxybenzeneboronic acid

Product 1

HCID 687002455-Bromo-1-(4-isopropoxyphenyl)indole-2-carboxylic acid ethyl ester

Procedure

The sub-title compound was prepared in accordance with Example 8(c) from 5-bromoindole-2-carboxylic acid ethyl ester and 4-isopropoxyphenylboronic acid.

Sources & evidence

ORD record
ord-33f2be1932fe40ca93bd652aee0bccf0
Source dataset
uspto-grants-2010_04
Patent number
US07705023B2

Reaction notes

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