4-Isopropoxybenzeneboronic acid → 5-Bromo-3-chloro-1-(4-isopropoxyphenyl)indole-2-carboxylic acid ethyl ester

HRID 646135Notes

Reaction equation

HRID 646135 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([C:14]=1[Cl:15])=[CH:12][C:11]([Br:16])=[CH:10][CH:9]=2)=[O:5])[CH3:2].[CH:17]([O:20][C:21]1[CH:26]=[CH:25][C:24](B(O)O)=[CH:23][CH:22]=1)([CH3:19])[CH3:18]>>[CH2:1]([O:3][C:4]([C:6]1[N:7]([C:24]2[CH:25]=[CH:26][C:21]([O:20][CH:17]([CH3:19])[CH3:18])=[CH:22][CH:23]=2)[C:8]2[C:13]([C:14]=1[Cl:15])=[CH:12][C:11]([Br:16])=[CH:10][CH:9]=2)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 36987264-Isopropoxybenzeneboronic acidHCID 28330549ethyl 5-bromo-3-chloro-1H-indole-2-carboxylate

Product 1

HCID 686966545-Bromo-3-chloro-1-(4-isopropoxyphenyl)indole-2-carboxylic acid ethyl ester

Procedure

The sub-title compound was prepared in accordance with Example 8(c), using 5-bromo-3-chloro-1H-indole-2-carboxylic acid ethyl ester (see step (a) above) and 4-isopropoxyphenylboronic acid.

Sources & evidence

ORD record
ord-196a7e97a2d04a5693538cec9d8fb558
Source dataset
uspto-grants-2010_04
Patent number
US07705023B2

Reaction notes

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