HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 646142Generated: October 28, 2026
Carbon Tetrachloride → 3-chloro-5-(5-trifluoromethylpyrid-2-yl)-1H-indole-2-carboxylic acid ethyl ester
https://huagongshe.com/reaction/646142
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Carbon Tetrachloride | HCID 5943 | — |
| Reactant | 5-(5-trifluoromethylpyrid-2-yl)-1H-indole-2-carboxylic acid ethyl ester | HCID 68472386 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-chloro-5-(5-trifluoromethylpyrid-2-yl)-1H-indole-2-carboxylic acid ethyl ester | HCID 68473534 | 98% |
Reaction Steps
N-Chlorosuccimimide (480 mg, 3.86 mmol) and 5-(5-trifluoromethylpyrid-2-yl)-1H-indole-2-carboxylic acid ethyl ester (800 mg, 2.4 mmol; see Example 8 (b)) were mixed in CCl4 (50 mL) and stirred at 80° C. for 2 h. The mixture was diluted with EtOAc and washed with Na2S2O3 (aq., sat.), NaHCO3 (aq., sat.), brine and dried over Na2SO4 Concentration gave the sub-title compound (870 mg, 98%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07705023B2 |
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| Source dataset | uspto-grants-2010_04 |
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| ORD ID | ord-c5099cb5a3a548c588d7aee20c6ccf6a |
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| Source note | uspto-grants-2010_04 |
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