3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine → HCID 68698489, compound

HRID 646163Notes

Reaction equation

HRID 646163 reaction equation
C([O:3][C:4]([C:6]1[N:7]([C:22]2[CH:27]=[CH:26][C:25]([O:28][CH:29]3[CH2:33][CH2:32][CH2:31][CH2:30]3)=[CH:24][CH:23]=2)[C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([C:15]1[N:20]=[CH:19][C:18](Br)=[CH:17][N:16]=1)=[CH:10][CH:9]=2)=[O:5])C.CC1(C)C(C)(C)OB([C:42]2[CH:43]=[N:44][CH:45]=[CH:46][CH:47]=2)O1>>[CH:29]1([O:28][C:25]2[CH:26]=[CH:27][C:22]([N:7]3[C:8]4[C:13](=[CH:12][C:11]([C:15]5[N:20]=[CH:19][C:18]([C:43]6[CH:42]=[CH:47][CH:46]=[CH:45][N:44]=6)=[CH:17][N:16]=5)=[CH:10][CH:9]=4)[CH:14]=[C:6]3[C:4]([OH:3])=[O:5])=[CH:23][CH:24]=2)[CH2:33][CH2:32][CH2:31][CH2:30]1

Participants

3

Reactant 2

HCID 27346563-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridineHCID 68700384HCID 68700384, compound

Product 1

HCID 68698489HCID 68698489, compound

Procedure

The title compound was prepared in accordance with Example 8(b) from 5-(5-bromopyrimidin-2-yl)-1-(4-cyclopentoxyphenyl)-1H-indole-2-carboxylic acid ethyl ester (see Example 48(g)) and 3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine, followed by ester hydrolysis in accordance with the procedure described in Example 35, Method 3, step (b).

Sources & evidence

ORD record
ord-65ca4f56a91d49f3bea2b9bb0b19827c
Source dataset
uspto-grants-2010_04
Patent number
US07705023B2

Reaction notes

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