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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 646172Generated: October 28, 2026

5-Bromo-2-(cyclopentyloxy)pyridine → 5-(4-tert-Butylphenyl)-1-(6-cyclopentoxypyrid-3-yl)-1H-indole-2-carboxylic acid

https://huagongshe.com/reaction/646172

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Bromo-2-(cyclopentyloxy)pyridineHCID 21914353—
ReactantEthyl 5-(4-(tert-butyl)phenyl)-1H-indole-2-carboxylateHCID 68475095—
Product5-(4-tert-Butylphenyl)-1-(6-cyclopentoxypyrid-3-yl)-1H-indole-2-carboxylic acidHCID 68701349—

Reaction Steps

The title compound was prepared in accordance with Example 1(b) from 5-(4-tert-butylphenyl)indole-2-carboxylic acid ethyl ester (see Example 1(a)) and 5-bromo-2-cyclopentoxypyridine (see Example 36(b)), followed by ester hydrolysis in accordance with the procedure described in Example 35, Method 3, step (b).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07705023B2
Source datasetuspto-grants-2010_04
ORD IDord-9f4c8db1253047119a34f1c695746a01
Source noteuspto-grants-2010_04