HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromopropane → 4-Bromo-1-isopropoxy-2-nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromopropane | HCID 6358 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 4-Bromo-2-nitrophenol | HCID 24364 | — |
| Reactant | 18-Crown-6 | HCID 28557 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 4-Bromo-1-isopropoxy-2-nitrobenzene | HCID 22283241 | 61.1% |
Reaction Steps
A mixture of 4-bromo-2-nitrophenol (2.17 g, 10 mmol), 2-bromopropane (2.44 g, 20 mmol), KOH (2.24 g, 40 mmol) and 18-crown-6 (224 mg, 1.0 mmol) in benzene (100 mL) was heated at reflux for 4 h. Cooling to room temperature, concentration and purification by chromatography afforded the sub-title compound (1.59 g, 61%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07705023B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-25b53e863bfc461c80753338c3a99595 |
| Source note | uspto-grants-2010_04 |