Quinoline-3-boronic acid → HCID 68699988, compound

HRID 646177Notes

Reaction equation

HRID 646177 reaction equation
C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([C:15]1[CH:20]=[CH:19][C:18]([C:21]([CH3:24])([CH3:23])[CH3:22])=[CH:17][CH:16]=1)=[CH:10][CH:9]=2)=[O:5])C.[N:25]1[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH:28]=[C:27](B(O)O)[CH:26]=1>>[C:21]([C:18]1[CH:17]=[CH:16][C:15]([C:11]2[CH:12]=[C:13]3[C:8](=[CH:9][CH:10]=2)[N:7]([C:27]2[CH:26]=[N:25][C:34]4[C:29]([CH:28]=2)=[CH:30][CH:31]=[CH:32][CH:33]=4)[C:6]([C:4]([OH:5])=[O:3])=[CH:14]3)=[CH:20][CH:19]=1)([CH3:24])([CH3:22])[CH3:23]

Participants

3

Reactant 2

HCID 2734663Quinoline-3-boronic acidHCID 68475095Ethyl 5-(4-(tert-butyl)phenyl)-1H-indole-2-carboxylate

Product 1

HCID 68699988HCID 68699988, compound

Procedure

The title compound was prepared in accordance with Example 8(c) from 5-(4-tert-butylphenyl)indole-2-carboxylic acid ethyl ester (see Example 1(a)) and quinoline-3-boronic acid , followed by ester hydrolysis in accordance with the procedure described in Example 35, Method 3, step (b).

Sources & evidence

ORD record
ord-7f74765448aa4075917c60330c1ece76
Source dataset
uspto-grants-2010_04
Patent number
US07705023B2

Reaction notes

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