Pyrrole-2-carboxaldehyde → HCID 6074183, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 1H-pyrrole-2-carbaldehyde (3.3 g, 34.7 mmol) and 4-chlorophenylacetonitrile (5.5 g, 33.0 mmol, 0.95 equivalents) in water (50 ml) was heated to 50° C. When all the solid material had melted, the vigorously stirred mixture was treated with 40% aqueous Triton B (14 ml, 5.6 mmol). Precipitation began almost immediately. Stirring was continued for 5 h at 50° C., breaking up lumps when necessary. The still warm suspension was filtered through a sintered glass funnel and washed with warm water. The yellow precipitate was dried at the pump (6.63 g). This is Compound 2 in TABLE 8.

Provenance & Evidence