1-Methyl-1H-pyrrole-2-carbaldehyde → HCID 5941874, compound

Participants

Reaction Steps

A suspension of 4-chlorophenylacetonitrile (500 mg, 3.30 mmol) and 1-methyl-1H-pyrrole-2-carbaldehyde (370 mg, 3.39 mmol, 1.03 equiv.) in water (5 ml) was treated with 40% aqueous Triton B (1.4 ml, 3.3 mmol). Precipitate began forming almost immediately. After stirring for 2 h, the precipitate was filtered off, washed with water, and dried to afford a yellow solid (682 mg). This is Compound 6 in Table 8.

Provenance & Evidence