Potassium Hydroxide → HCID 11536549, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-chlorophenylacetonitrile (500 mg, 3.30 mmol), 1-ethoxymethyl-1H-pyrrole-2-carbaldehyde (520 mg, 3.39 mmol, 1.03 equiv.), and 18-crown-6 ether as a phase transfer catalyst (87 mg, 0.33 mmol) in toluene (30 ml) was added potassium hydroxide (185 mg, 3.30 mmol) and the mixture was heated to 80° C. for 3 h, then stirred at room temperature overnight. The solution was filtered through a small plug of silica and concentrated to afford an oil (705 mg). This is Compound 7 in Table 8.

Provenance & Evidence