関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Pyrrole-2-carboxaldehyde | HCID 13854 | — |
| 反応物 | 2-(o-Tolyl)acetonitrile | HCID 31155 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | HCID 11564718 | HCID 11564718 | 30.5% |
反応手順
A thick walled tube was charged with 1H-pyrrole-2-carbaldehyde (2.0 g, 21.0 mmol), 2-methylphenylacetonitrile (2.5 g, 18.9 mmol, 0.9 equivalents), ethanol (75 ml), and 40% aqueous Triton B (4.0 ml, 3.3 mmol). The tube was sealed and heated to 90° C. for 4 days. Removal of the solvent, followed by chromatography on silica gel using dichloromethane/petroleum spirits (20:80) as eluant afforded a yellow solid (1.2 g). This is Compound 16 in Table 8.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07705038B2 |
|---|
| 出典データセット | uspto-grants-2010_04 |
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| ORD ID | ord-f0f6894a5e0e45489252798d02e21b8b |
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| 出典メモ | uspto-grants-2010_04 |
|---|
