Potassium Carbonate → HCID 44430595, compound

Participants

Reaction Steps

A solution of (Z)-2-(4-Chloro-phenyl)-3-(1H-pyrrol-2-yl)acrylonitrile being Compound 2 in Table 8 (200 mg, 0.875 mmol) in dry acetone (35 ml) was treated with K2CO3 (121 mg) followed by dimethylallyl bromide (111 μl, 0.962 mmol, 1.1 equivalents). The mixture was heated to a gentle reflux for 20 h. The reaction was cooled to room temperature and filtered. The filtrate was chromatographed on silica gel using ethylacetate/petroleum spirits (1:1) as eluant to afford the title compound as a yellow oil (85 mg). This is Compound 80 in Table 8.

Provenance & Evidence