反应详情

A mixture of 3.393 g (7.04 mM) of 2-amino-9-[(2-benzoyloxy-1-(benzoyloxymethyl)ethoxy)methyl]-6-chloro-9H-purine, 100 ml ethanol, 100 ml tetrahydrofuran, 1.9 ml triethylamine was added to 0.6 g Pd-C catalyst in a Parr bottle. The mixture was shaken under 50 P.S.I. of H2 for 24 hours. The Pd-C was filtered through a Celite pad and 0.65 g fresh Pd-C was added to the reaction mixture and the hydrogenation was continued for 4 days. Column chromatography using 100% CH2Cl2, 4:1 CH2Cl2 /acetone, and 100% acetone produced the title compound, mpt. 132°-133° C.

1. filtrationThe Pd-C was filtered through a Celite pad and 0.65 g fresh Pd-C
2. additionwas added to the reaction mixture
3. waitthe hydrogenation was continued for 4 days