2-phenylethynylboronic Acid → HCID 59772708, compound

HRID 646260Notes

Reaction equation

HRID 646260 reaction equation
[NH2:1][C:2]1[N:3]([CH3:26])[C:4](=[O:25])[C:5]([C:14]2[CH:15]=[C:16]([CH:23]=[O:24])[N:17]([CH2:19][CH2:20][CH2:21][F:22])[CH:18]=2)([C:7]2[CH:12]=[CH:11][CH:10]=[C:9](Br)[CH:8]=2)[N:6]=1.[C:27]1([C:33]#[C:34]B(O)O)[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[NH2:1][C:2]1[N:3]([CH3:26])[C:4](=[O:25])[C:5]([C:14]2[CH:15]=[C:16]([CH:23]=[O:24])[N:17]([CH2:19][CH2:20][CH2:21][F:22])[CH:18]=2)([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:34]#[C:33][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[CH:8]=2)[N:6]=1

Participants

3

Reactant 2

HCID 109425742-phenylethynylboronic AcidHCID 59772727HCID 59772727, compound

Product 1

HCID 59772708HCID 59772708, compound

Procedure

Using essentially the same procedure described in Example 200 and employing 4-{2-amino-1-methyl-5-oxo-4-(3-bromophenyl)-4,5-dihydro-1H-imidazol-4-yl}-1-(3-fluoropropyl)-1H-pyrrole-2-carbaldehyde and phenylethyneboronic acid, the title compound was obtained as a white solid, mp 85-90° C., identified by NMR and mass spectral analyses.

Sources & evidence

ORD record
ord-d3ae039d44fe4bfc9df09b1d71ee1d05
Source dataset
uspto-grants-2010_04
Patent number
US07705030B2

Reaction notes

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