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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 646359Generated: October 29, 2026

Pyrrolidin-1-amine monohydrochloride → 4-methoxy-N-pyrrolidin-1-yl-3-[(E)-2-(4-trifluoromethoxyphenyl)-vinyl]benzamide

https://huagongshe.com/reaction/646359

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPyrrolidin-1-amine monohydrochlorideHCID 3017392—
Reactant4-methoxy-3-[(E)-2-(4-trifluoromethoxyphenyl)vinyl]benzoic acidHCID 23141498—
Product4-methoxy-N-pyrrolidin-1-yl-3-[(E)-2-(4-trifluoromethoxyphenyl)-vinyl]benzamideHCID 23141389—

Reaction Steps

The captioned compound was synthesized from 4-methoxy-3-[(E)-2-(4-trifluormethoxyphenyl)vinyl]benzoic acid obtained in step B of Example 2-2-1 and 1-aminopyrrolidine hydrochloride in accordance with the same procedure as in the methods described in step C of Example 1-2-3.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07705053B2
Source datasetuspto-grants-2010_04
ORD IDord-d490b097fd82403a8fd3a4c1796c6949
Source noteuspto-grants-2010_04