2-Aminopropanol → N-(2-hydroxy-1-methylethyl)-4-methoxy-3-[(E)-2-(4-trifluoromethylphenyl)-vinyl]benzamide

HRID 646381Notes

Reaction equation

HRID 646381 reaction equation
[OH:1][CH:2](CO)[CH2:3][NH:4][C:5](=[O:26])[C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8](/[CH:14]=[CH:15]/[C:16]2[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=2)[CH:7]=1.N[CH:30](C)CO>>[OH:1][CH2:2][CH:3]([NH:4][C:5](=[O:26])[C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8](/[CH:14]=[CH:15]/[C:16]2[CH:17]=[CH:18][C:19]([C:22]([F:23])([F:25])[F:24])=[CH:20][CH:21]=2)[CH:7]=1)[CH3:30]

Participants

3

Reactant 2

HCID 51262-AminopropanolHCID 23141417N-(2,3-dihydroxy-propyl)-4-methoxy-3-[(E)-2-(4-trifluoromethylphenyl)vinyl]benzamide

Product 1

HCID 23141447N-(2-hydroxy-1-methylethyl)-4-methoxy-3-[(E)-2-(4-trifluoromethylphenyl)-vinyl]benzamide

Procedure

The captioned compound was synthesized from 4-methoxy-3-[(E)-2-(4-trifluoromethylphenyl)vinyl]benzoic acid obtained in step B of Example 2-2-38 and (±)-2-amino-1-propanol in accordance with the same procedure as in the methods described in step C of Example 1-2-3.

Sources & evidence

ORD record
ord-b8ae7298d1514c4995f8cb1928239b9e
Source dataset
uspto-grants-2010_04
Patent number
US07705053B2

Reaction notes

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