2-Fluoro-4-(trifluoromethyl)benzyl bromide → 3-[(E)-2-(2-fluoro-4-trifluoromethyl-phenyl)-vinyl]-benzamide

HRID 646393Notes

Reaction equation

HRID 646393 reaction equation
[F:1][C:2]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:3]=1[CH2:4]Br.[CH:14]([C:16]1[CH:17]=[C:18]([CH:22]=[CH:23][C:24]=1OC)[C:19]([NH2:21])=[O:20])=O>>[F:1][C:2]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:3]=1/[CH:4]=[CH:14]/[C:16]1[CH:17]=[C:18]([CH:22]=[CH:23][CH:24]=1)[C:19]([NH2:21])=[O:20]

Participants

3

Reactant 2

HCID 27375702-Fluoro-4-(trifluoromethyl)benzyl bromideHCID 231413863-Formyl-4-methoxybenzamide

Product 1

HCID 231415053-[(E)-2-(2-fluoro-4-trifluoromethyl-phenyl)-vinyl]-benzamide

Procedure

The captioned compound was synthesized from 2-fluoro-4-trifluoromethylbenzyl bromide and 3-formyl-4-methoxybenzamide by the same procedure as in the manufacturing method described in Example 2-3-6.

Sources & evidence

ORD record
ord-90d70baad5c140ad89ca5d2f9cb4af4a
Source dataset
uspto-grants-2010_04
Patent number
US07705053B2

Reaction notes

Loading…