Sodium Hydroxide → HCID 59174089, compound

Participants

Reaction Steps

4-[4-(1-Acetylamino-1-methyl-ethyl)-thiazol-2-yl]-benzoic acid ethyl ester (0.13 g, 0.39 mmol) is dissolved in 2 mL tetrahydrofuran and 2 mL ethanol. 2N sodium hydroxide (1.17 mmol, 0.587 mL) is added and the mixture is heated to reflux for 1 hour. The reaction is concentrated to dryness and the resulting residue is dissolved in 95:5 dichloromethane/isopropanol layered with 0.1N HCl. The organics are separated and dried over sodium sulfate, filtered, and concentrated to give 0.106 g of the pure titled compound. MS (m/e) 303.2 (M−H)−

Provenance & Evidence