Hydrogen Bromide → HCID 59264667, compound

Participants

Reaction Steps

To a stirring solution of 4-[4-(1-Amino-1-methyl-ethyl)-thiazol-2-yl]-benzoic acid ethyl ester:hydrobromide (11.0 mmol) and n-methylmorpholine (2.0 mmol) in dichloromethane (0.10M), add benzoyl chloride (1.0 mmol) diluted in 2 mL dichloromethane. Stir at room temperature for 20 minutes. Wash the reaction with water while extracting with dichloromethane. Dry the organic layer with sodium sulfate, filter and concentrate in vacuo. Purify via radial chromatography eluting with ethyl acetate and hexane. MS (m/e): 395.2 (M+H)+

Provenance & Evidence