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HRID646410

反应详情

EQUATION

反应方程式

HRID 646410 的结构方程式

REACTANTS

反应物

2
结构：CC1(C)OB(c2ccc(C(=O)O)c(F)c2)OC1(C)C
HCID44717665

2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid

C13H16BFO4

结构：C[C@@H]1CCCN1C[C@@H]1CCCN1
HCID46911921

(2R)-2-Methyl-1-{[(2S)-pyrrolidin-2-yl]methyl}pyrrolidine

C10H20N2

PRODUCTS

生成物

1
结构：C[C@@H]1CCCN1C[C@@H]1CCCN1C(=O)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1F
HCID57980040

未命名化合物

PROCEDURE

实验过程

A 100 mL toluene/EtOH mixture of commercially available 4-carboxy-3-phenyl boronic acid and pinacol is stirred at 75-80° C. for 2 hours, then concentrated, slurried in toluene, concentrated, and dried in vacuo to give 2-Fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoic acid that is used without further purification. The title intermediate is prepared in a manner substantially analogous. General Procedure E using 2-(R)-methyl-1-(2-(S)-pyrrolidinylmethyl)pyrrolidine and 2-Fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoic acid. The crude product is confirmed by NMR and MS (MS+) 417.5 (M+H)+ then used without further purification.

WORKUP

后处理

  1. customis used without further purification
  2. custom(M+H)+ then used without further purification