反应详情

A 25 mL THF/MeOH (2:1) solution of 2-Bromo-5-ethylsulfanyl-thiophene (CAS 19991-60-7) is stirred at 0-10° C. while 8 mL H2O, then 3 equivalents of Oxone are added. The reaction mixture is stirred three hours at room temperature, then is diluted with CH2Cl2, filtered, washed with aq. NaHCO3 and brine, dried (Na2SO4) and concentrated in vacuo. The crude mixture is purified by silica gel column chromatography (gradient: 0-20% EtOAc/CH2Cl2) to give title intermediate that is confirmed by NMR.

1. filtrationfiltered
2. washwashed with aq. NaHCO3 and brine
3. dry with materialdried (Na2SO4)
4. concentrationconcentrated in vacuo
5. customThe crude mixture is purified by silica gel column chromatography (gradient: 0-20% EtOAc/CH2Cl2)
6. customto give title intermediate that