HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → HCID 59264674, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 5-Bromothiophene-2-carbaldehyde | HCID 78428 | — |
| Reactant | O-Methylhydroxylamine hydrochloride | HCID 521874 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 59264674 | HCID 59264674 | — |
Reaction Steps
Methoxylamine HCl (1 equivalent) is added portionwise to a stirred pyridine (1 equivalent) solution of 5-bromo-2-thiophene carboxaldehyde (1 equivalent) (CAS 4701-17-1). After 18 hours, reaction is diluted with CH2Cl2 and washed with brine, dried (Na2SO4) and concentrated in vacuo. The crude mixture is purified by silica gel column chromatography (gradient: 0-20% EtOAc/hexanes) to give title intermediate that is confirmed by NMR.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07705025B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-b395d2196433437888d537d719570804 |
| Source note | uspto-grants-2010_04 |