HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Hydroxybenzotriazole → HCID 11517346, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidine | HCID 853152 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | Lithium | HCID 3028194 | — |
| Reactant | 4-(5-Sulfamoylthiophen-2-yl)benzoic acid | HCID 53426311 | — |
| Solvent | dichloromethane N,N-dimethylformamide | HCID 22350042 | — |
| Product | HCID 11517346 | HCID 11517346 | 34% |
Reaction Steps
The title compound is prepared in a manner substantially analogous to General Procedure D in 9 mL 50% DMF/dichloromethane using 4-(5-Sulfamoyl-thiophen-2-yl)-benzoic acid, lithium salt (173 mg, 0.61 mmol), EDC-HCl (174 mg, 0.91 mmol), HOBt (123 mg, 0.91 mmol), DIEA (0.26 mL, 1.5 mmol) and (S)(+)-1-(2-pyrrolidinylmethyl)pyrrolidine (79 mg, 0.51 mmol) to give the title compound (74 mg, 34% yield). MS (ES+) 420.2 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07705025B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-58483fd553a445e7934b9bdb9147c64e |
| Source note | uspto-grants-2010_04 |