HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Hydroxybenzotriazole → HCID 11639623, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidine | HCID 853152 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | Lithium | HCID 3028194 | — |
| Reactant | HCID 59264689 | HCID 59264689 | — |
| Solvent | dichloromethane N,N-dimethylformamide | HCID 22350042 | — |
| Product | HCID 11639623 | HCID 11639623 | 71% |
Reaction Steps
The title compound is prepared in a manner substantially analogous to General Procedure D in 8 mL 37% DMF/dichloromethane using 4-(5-methylsulfanyl-thiophen-2-yl)-benzoic acid, Lithium salt (51 mg, 0.20 mmol), EDC-HCl (57 mg, 0.30 mmol), HOBt (41 mg, 0.30 mmol), DIEA (0.09 mL, 0.5 mmol) and (S)(+)-1-(2-pyrrolidinylmethyl)pyrrolidine (28 mg, 0.18 mmol) to give the title compound (50 mg, 71% yield). MS (ES+) 387.7 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07705025B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-32e12f58c23c4a40999816e76c0cb1b9 |
| Source note | uspto-grants-2010_04 |