HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Hydroxybenzotriazole → HCID 11582478, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidine | HCID 853152 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | Lithium | HCID 3028194 | — |
| Reactant | HCID 59264695 | HCID 59264695 | — |
| Solvent | dichloromethane N,N-dimethylformamide | HCID 22350042 | — |
| Product | HCID 11582478 | HCID 11582478 | 57% |
Reaction Steps
The title compound is prepared in a manner substantially analogous to General Procedure D in 8 mL 37% DMF/dichloromethane using 4-(5-methanesulfonyl-thiophen-2-yl)-benzoic acid, Lithium salt (92 mg, 0.32 mmol), EDC-HCl (92 mg, 0.48 mmol), HOBt (65 mg, 0.48 mmol), DIEA (0.14 mL, 0.8 mmol) and (S)(+)-1-(2-pyrrolidinylmethyl)pyrrolidine (45 mg, 0.29 mmol) to give the title compound (60 mg, 57% yield). MS (ES+) 419.2 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07705025B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-09cb477e5aa040318ebc36697db49be3 |
| Source note | uspto-grants-2010_04 |