HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Hydroxybenzotriazole → HCID 11696286, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidine | HCID 853152 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | Lithium | HCID 3028194 | — |
| Reactant | HCID 18946849 | HCID 18946849 | — |
| Solvent | dichloromethane N,N-dimethylformamide | HCID 22350042 | — |
| Product | HCID 11696286 | HCID 11696286 | 66% |
Reaction Steps
The title compound is prepared in a manner substantially analogous to General Procedure D in 5 mL 20% DMF/dichloromethane using 4-(2-cyano-thiophen-3-yl)-benzoic acid, lithium salt (141 mg, 0.60 mmol), EDC-HCl (143 mg, 0.75 mmol), HOBt (101 mg, 0.75 mmol), DIEA (0.24 mL, 1.4 mmol) and (S)(+)-1-(2-pyrrolidinylmethyl)pyrrolidine (77 mg, 0.50 mmol) to give the title compound (120 mg, 66% yield). MS (ES+) 366.3 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07705025B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-75d546c56c80434591ad6d01dbc44be5 |
| Source note | uspto-grants-2010_04 |