(S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidine → HCID 11546232, compound

HRID 646427Notes

Reaction equation

HRID 646427 reaction equation
[Br:1][C:2]1[S:6][C:5]([C:7]2[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[NH:16]1[CH2:20][CH2:19][CH2:18][C@H:17]1[CH2:21][N:22]1[CH2:26][CH2:25][CH2:24][CH2:23]1>>[Br:1][C:2]1[S:6][C:5]([C:7]2[CH:8]=[CH:9][C:10]([C:11]([N:16]3[CH2:20][CH2:19][CH2:18][C@H:17]3[CH2:21][N:22]3[CH2:26][CH2:25][CH2:24][CH2:23]3)=[O:13])=[CH:14][CH:15]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 853152(S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidineHCID 10469017HCID 10469017, compound

Product 1

HCID 11546232HCID 11546232, compound

Procedure

The title compound is prepared in a manner substantially analogous to General Procedure D using 4-(5-Bromo-thiophen-2-yl)-benzoic acid (CAS 1545208-54-4) and (S)(+)-1-(2-pyrrolidinylmethyl)pyrrolidine to give the title compound (5.42 g). MS (ES+) 419.0 (M+H)+

Workup

  1. customThe title compound is prepared in a manner substantially analogous to General Procedure D

Sources & evidence

ORD record
ord-828f4f74c8b34edabde80c7054124f9f
Source dataset
uspto-grants-2010_04
Patent number
US07705025B2

Reaction notes

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