HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidine → (2(S)-Pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-(6-thiophen-2-yl-pyridin-3-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidine | HCID 853152 | — |
| Reactant | 6-(Thiophen-2-Yl)Pyridine-3-Carboxylic Acid | HCID 15411144 | — |
| Product | (2(S)-Pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-(6-thiophen-2-yl-pyridin-3-yl)-methanone | HCID 11508383 | — |
Reaction Steps
The title compound is prepared in a manner substantially analogous to General Procedure D using 6-thiophen-2-yl-nicotinic acid (CAS 179408-54-9) and (S)(+)-1-(2-pyrrolidinylmethyl)pyrrolidine to give the title compound (58 mg). MS (ES+) 342.1 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07705025B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-5b3d7a16dfeb4276b105e2cd2a7d2507 |
| Source note | uspto-grants-2010_04 |