(R)-2-methyl-1-((S)-pyrrolidin-2-ylmethyl)pyrrolidine → HCID 11575657, compound

HRID 646431Notes

Reaction equation

HRID 646431 reaction equation
CO[C:3](=[O:19])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]([S:15]([CH3:18])(=[O:17])=[O:16])[S:13][CH:14]=2)=[CH:6][CH:5]=1.[CH3:20][C@@H:21]1[CH2:25][CH2:24][CH2:23][N:22]1[CH2:26][C@@H:27]1[CH2:31][CH2:30][CH2:29][NH:28]1>>[CH3:18][S:15]([C:12]1[S:13][CH:14]=[C:10]([C:7]2[CH:6]=[CH:5][C:4]([C:3]([N:28]3[CH2:29][CH2:30][CH2:31][C@H:27]3[CH2:26][N:22]3[CH2:23][CH2:24][CH2:25][C@H:21]3[CH3:20])=[O:19])=[CH:9][CH:8]=2)[N:11]=1)(=[O:16])=[O:17]

Participants

3

Reactant 2

HCID 46911921(R)-2-methyl-1-((S)-pyrrolidin-2-ylmethyl)pyrrolidineHCID 59264673HCID 59264673, compound

Product 1

HCID 11575657HCID 11575657, compound

Procedure

The title compound is prepared in a manner substantially analogous to Procedure N and Procedure P starting from 4-(2-Methanesulfonyl-thiazol-4-yl)-benzoic acid methyl ester and 2-(R)-Methyl-1-(2-(S)-pyrrolidinylmethyl)pyrrolidine. MS (ES+) 434.12.

Sources & evidence

ORD record
ord-d78b5c1a42834f66994e2c7998f7148b
Source dataset
uspto-grants-2010_04
Patent number
US07705025B2

Reaction notes

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