HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylthiophene-2-boronic acid → [4-(4-Methyl-thiophen-2-yl)-phenyl]-((S)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylthiophene-2-boronic acid | HCID 2734373 | — |
| Reactant | (4-Bromo-phenyl)-(2-pyrrolidin-1-ylmethyl-pyrrolidin-yl)methanone | HCID 11964813 | — |
| Product | [4-(4-Methyl-thiophen-2-yl)-phenyl]-((S)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone | HCID 11631736 | — |
Reaction Steps
The title compound is prepared in a manner substantially analogous to Procedure Q starting from 4-Methyl-2-thiophene boronic acid and 4-(2-Pyrrolidin-1-ylmethyl-pyrrolidine-1-carbonyl)-phenyl bromide to give 70 mg (67%). MS (ES+) 355.2
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07705025B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-29b4bf06a7a744d9bdb77f33c9e9935f |
| Source note | uspto-grants-2010_04 |