HuagongsheHuagongshe Chemistry Print Report · For research reference only
(5-Acetylthiophen-2-yl)boronic acid → 1-{5-[4-((S)-2-Pyrrolidin-1-ylmethyl-pyrrolidine-1-carbonyl)-phenyl]-thiophen-2-yl}-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (5-Acetylthiophen-2-yl)boronic acid | HCID 4143377 | — |
| Reactant | (4-Bromo-phenyl)-(2-pyrrolidin-1-ylmethyl-pyrrolidin-yl)methanone | HCID 11964813 | — |
| Product | 1-{5-[4-((S)-2-Pyrrolidin-1-ylmethyl-pyrrolidine-1-carbonyl)-phenyl]-thiophen-2-yl}-ethanone | HCID 11646649 | — |
Reaction Steps
The title compound is prepared in a manner substantially analogous to Procedure Q starting from 5-Acetyl-2-thiophene boronic acid and 4-(2-Pyrrolidin-1-ylmethyl-pyrrolidine-1-carbonyl)-phenyl bromide to give 42 mg (37%). MS (ES+) 383.2
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07705025B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-0fa13721827b4c289bbde79f6f506ebc |
| Source note | uspto-grants-2010_04 |