Thiophene-3-boronic acid → HCID 11617061, compound

HRID 646435Notes

Reaction equation

HRID 646435 reaction equation
[S:1]1[CH:5]=[CH:4][C:3](B(O)O)=[CH:2]1.[N:9]1([CH2:14][CH:15]2[CH2:19][CH2:18][CH2:17][N:16]2[C:20]([C:22]2[CH:27]=[CH:26][C:25](Br)=[CH:24][CH:23]=2)=[O:21])[CH2:13][CH2:12][CH2:11][CH2:10]1>>[N:9]1([CH2:14][C@@H:15]2[CH2:19][CH2:18][CH2:17][N:16]2[C:20]([C:22]2[CH:23]=[CH:24][C:25]([C:3]3[CH:4]=[CH:5][S:1][CH:2]=3)=[CH:26][CH:27]=2)=[O:21])[CH2:10][CH2:11][CH2:12][CH2:13]1

Participants

3

Reactant 2

HCID 581760Thiophene-3-boronic acidHCID 11964813(4-Bromo-phenyl)-(2-pyrrolidin-1-ylmethyl-pyrrolidin-yl)methanone

Product 1

HCID 11617061HCID 11617061, compound

Procedure

The title compound is prepared in a manner substantially analogous to Procedure Q starting from 3-Thiophene boronic acid and 4-(2-Pyrrolidin-1-ylmethyl-pyrrolidine-1-carbonyl)-phenyl bromide to give 56 mg (56%). MS (ES+) 341.2

Workup

  1. customto give 56 mg (56%)

Sources & evidence

ORD record
ord-27cc17d93f9947d99dd24df87a3bcec0
Source dataset
uspto-grants-2010_04
Patent number
US07705025B2

Reaction notes

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