2-Thiopheneboronic acid → HCID 11508742, compound

HRID 646436Notes

Reaction equation

HRID 646436 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1B(O)O.Br[C:10]1[CH:15]=[CH:14][C:13]([C:16]([N:18]2[CH2:22][CH2:21][CH2:20][C@H:19]2[CH2:23][N:24]2[CH2:28][CH2:27][CH2:26][CH2:25]2)=[O:17])=[C:12]([F:29])[CH:11]=1>>[F:29][C:12]1[CH:11]=[C:10]([C:2]2[S:1][CH:5]=[CH:4][CH:3]=2)[CH:15]=[CH:14][C:13]=1[C:16]([N:18]1[CH2:22][CH2:21][CH2:20][C@H:19]1[CH2:23][N:24]1[CH2:28][CH2:27][CH2:26][CH2:25]1)=[O:17]

Participants

3

Reactant 2

HCID 27339602-Thiopheneboronic acidHCID 11965125(4-Bromo-2-fluoro-phenyl)-((S)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone

Product 1

HCID 11508742HCID 11508742, compound

Procedure

The title compound is prepared in a manner substantially analogous to Procedure Q starting from 2-thiophene boronic acid and (4-Bromo-2-fluoro-phenyl)-((S)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone to give 29 mg (58%). MS (ES+) 359.1

Workup

  1. customto give 29 mg (58%)

Sources & evidence

ORD record
ord-fabb2d1d323445d7b151d790e5576f61
Source dataset
uspto-grants-2010_04
Patent number
US07705025B2

Reaction notes

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