[2-(S)-(2-(R)-Methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-methanone → {4-[5-(Azetidine-1-carbonyl)-thiophen-2-yl]-phenyl}-[2-(S)-(2-(R)-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-methanone

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Reaction Steps

The title compound is prepared in a manner substantially analogous to General Procedure A using [2-(S)-(2-(R)-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-methanone (367 mg, 0.92 mmol) and azetidin-1-yl-(5-bromo-thiophen-2-yl)-methanone) (226 mg, 0.92 mmol) to give 80 mg (21% yield). MS (ES+) 438.3 (M+H)+

Provenance & Evidence