[2-(S)-(2-(R)-Methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-methanone → [2-(S)-(2-(R)-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-{4-[5-(pyrrolidine-1-carbonyl)-thiazol-2-yl]-phenyl}-methanone

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Reaction Steps

The title compound is prepared in a manner substantially analogous to General Procedure A using [2-(S)-(2-(R)-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-methanone (199 mg, 0.5 mmol) and (2-bromo-thiazol-5-yl)-pyrrolidin-1-yl-methanone (120 mg, 0.46 mmol) to give 30 mg (14% yield). MS (ES+) 453.3 (M+H)+

Provenance & Evidence