HRID646443

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID17390281

2-Bromo-5-(methanesulfonyl)thiophene

C5H5BrO2S2

结构：C[C@@H]1CCCN1C[C@@H]1CCCN1C(=O)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1F

HCID57980040

未命名化合物

PRODUCTS

生成物

结构：C[C@@H]1CCCN1C[C@@H]1CCCN1C(=O)c1ccc(-c2ccc(S(C)(=O)=O)s2)cc1F

HCID59264696

未命名化合物

收率 78%

PROCEDURE

实验过程

The title compound is prepared in a manner substantially analogous to General Procedure A using [2-Fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-[2-(S)-(2-(R)-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-methanone (458 mg, 1.1 mmol) and 2-Bromo-5-methanesulfonyl-thiophene (CAS 2160-61-4) (255 mg, 1.0 mmol) to give 350 mg (78% yield). MS (ES+) 451.2 (M+H)+

WORKUP

后处理

customto give 350 mg (78% yield)