Acetone → HCID 86607366, compound

Participants

Reaction Steps

N-methacryloyl-6-aminocaproic acid (3.98 g, 20 mmol) was dissolved in 50 ml of acetone, and then to this solution 1,3-dicyclohexlylcarbodiimide (4.5 g, 22 mmol) and N-hydroxysuccinimide (2.55 g, 22 mmol) were added. Resulting mixture was stirred at room temperature for 6 hours. The reaction was quenched by addition of 1 ml of water, the precipitate of 1,3-dicyclohexylurea was removed by filtration and washed with acetone. The solution was concentrated in vacuum and purified by column chromatography on silica gel using step gradient of acetone (0-5%) in chlorophorm to give activated ester (3, Met=b, n=2) with yield 81% (4.8 g). MALDI MS: found 296.1, C14H20N2O5, calc. 296.09.

Provenance & Evidence