Boron Trichloride → HCID 136335803, compound

HRID 646465Notes

Reaction equation

B(Cl)(Cl)Cl.C([O:12][C:13]1[CH:18]=[C:17]([O:19]CC2C=CC=CC=2)[C:16]([CH:27]=[CH:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[CH:15][C:14]=1[C:35]1[O:39][N:38]=[C:37]([CH3:40])[C:36]=1[C:41]1[CH:46]=[CH:45][C:44]([O:47][CH3:48])=[CH:43][CH:42]=1)C1C=CC=CC=1>>[CH3:48][O:47][C:44]1[CH:43]=[CH:42][C:41]([C:36]2[C:37]([CH3:40])=[N:38][O:39][C:35]=2[C:14]2[CH:15]=[C:16]([CH:27]=[CH:28][C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)[C:17]([OH:19])=[CH:18][C:13]=2[OH:12])=[CH:46][CH:45]=1

Participants

Reactant 2

HCID 25135Boron Trichloride

HCID 68453143HCID 68453143, compound

Product 1

HCID 136335803HCID 136335803, compound

Procedure

Similarly, 4-[4-(4-methoxy-phenyl)-3-methyl-isoxazol-5-yl]-6-styryl-benzene-1,3-diol (Example 24) was prepared by boron trichloride deprotection of 5-(2,4-Bis-benzyloxy-5-styryl-phenyl)-4-(4-methoxy-phenyl)-3-methyl-isoxazole (prepared from styryl boronic acid coupling of bromo isoxazole intermediate, Example 3))

Sources & evidence

ORD record: ord-4188118fa5d340f78e479a35d4d44c9a
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07705027B2

Reaction notes

Loading…