Sodium Hydroxide → 2-(5-Fluoro-6-trifluoromethyl-1H-indol-2-yl)-1-(2,2,2-trifluoro-ethylsulfanyl)-butan-2-ol

HRID 646572Notes

Reaction equation

HRID 646572 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[C:11]([F:14])([F:13])[F:12])[N:7](S(C)(=O)=O)[C:6]([C:19]([OH:29])([CH2:27][CH3:28])[CH2:20][S:21][CH2:22][C:23]([F:26])([F:25])[F:24])=[CH:5]2.[OH-].[Na+]>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[C:11]([F:13])([F:14])[F:12])[NH:7][C:6]([C:19]([OH:29])([CH2:27][CH3:28])[CH2:20][S:21][CH2:22][C:23]([F:25])([F:24])[F:26])=[CH:5]2

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 115328422-(5-fluoro-1-methanesulfonyl-6-trifluoromethyl-1H-indol-2-yl)-1-(2,2,2-trifluoro-ethylsulfanyl)-butan-2-ol

Product 1

HCID 114948132-(5-Fluoro-6-trifluoromethyl-1H-indol-2-yl)-1-(2,2,2-trifluoro-ethylsulfanyl)-butan-2-ol

Procedure

This compound was prepared using the general de-protection procedure as describe in General Procedures Example B, reacting 2-(5-fluoro-1-methanesulfonyl-6-trifluoromethyl-1H-indol-2-yl)-1-(2,2,2-trifluoro-ethylsulfanyl)-butan-2-ol (0.59 g, 1.26 mmol) and using 4N sodium hydroxide as base (1 mL, 4.0 mmol) to yield the title compound as a solid.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-f4d502e78a5a421e981b5b427bcf86be
Source dataset
uspto-grants-2010_04
Patent number
US07705147B2

Reaction notes

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