Ammonia → Nitrilotripropionamide

HRID 64666Notes

Reaction equation

HRID 64666 reaction equation
[C:1]([NH2:5])(=[O:4])[CH:2]=[CH2:3].[NH3:6]>>[N:6]([CH2:3][CH2:2][C:1]([NH2:5])=[O:4])([CH2:3][CH2:2][C:1]([NH2:5])=[O:4])[CH2:3][CH2:2][C:1]([NH2:5])=[O:4]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 6579Acrylamide

Product 1

HCID 75874Nitrilotripropionamide

Conditions

Temperature
65 °C

Procedure

A Parr autoclave was charged with an aqueous solution of acrylamide and a 10% molar excess of aqueous ammonia. The resulting mixture was warmed to 65° C. and autogenous pressure (<50 psi) and stirred at these conditions for three hours. At the end of this period, the reaction mass was allowed to cool to room temperature and white, crystalline nitrilotripropionamide (melting range 184°-186° C.) was recovered. NMR spectroscopy confirmed the structure.

Workup

  1. temperatureto cool to room temperature
  2. customwhite, crystalline nitrilotripropionamide (melting range 184°-186° C.) was recovered

Sources & evidence

ORD record
ord-1967898e142a45609c6910a8a1448442
Source dataset
uspto-grants-1986_09
Patent number
US04609722

Reaction notes

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